On the ordinate axis – the proliferative activity of T-lymphocytes, on the abscissa axis – the values of the average UPP.
To detect the influence of cerebral energy processes, described using the characteristics of SCP, on immunological parameters, additional factor analysis was performed. For this characteristic, the SCP was divided into three subgroups: the mean group plus or minus the mean square deviation fell into the middle group, and the smaller and larger SCP values fell into the other two groups. The analysis basically confirmed the patterns found earlier. A meaningful interpretation of SCP factors that they reflect the activity of the activity of the corresponding brain formations that influence the immune processes. Significant factors were found in groups of subjects of young and old age.
In the group of young subjects, the hemispheric asymmetry of energy metabolism, reflected in the hemispheric difference of SCP, is a factor affecting the functional activity of T-lymphocytes . In addition, the proliferative activity of T-and B-lymphocytes depends on the processes that determine the amount of local SCP in the left temporal region.
Groups G1, G2, G3 – consist of the subjects, in which the SCP is higher, equal or lower in the left temporal lead compared to the right. F – Fisher criterion, p – level of significance. The ordinate axis is the proliferative activity of T-lymphocytes.
Analysis of variance in the group of elderly subjects revealed that the main factors affecting the immunological characteristics are cerebral processes that determine the inter-hemispheric difference of SCP, averaged SCP, as well as local potentials in the frontal and central areas .
With an increase in the hemispheric difference UPP, an increase in the functional activity of T-and B-lymphocytes is observed. Judging by statistical criteria, functional asymmetry most noticeably affects T-lymphocytes . With a general rise in cerebral energy metabolism (averaged UPP), the activity of T- and B-lymphocytes decreases , the effect on the proliferative activity of T-lymphocytes is also more noticeable than on B-cells . The increase in energy metabolism in the brain as a whole is associated with the activation of large areas of the cortex and may be the result of stress. The decrease in the activity of lymphocytes during the growth of energy exchange in the brain confirms the idea that the activation of the brain, apparently through stress mechanisms, has a inhibitory effect on immune processes. This corresponds to the correlation between the level of stress hormone cortisol in the blood and immune characteristics. Reliable values of the coefficient of multiple correlation were identified, linking cortisol with many characteristics of the proliferative activity of T and B lymphocytes ( R = 0.97; p <0.002). The total number of lymphocytes decreases with cortisol growth.
From literature data it is known that the right hemisphere is more closely associated with the regulation of immune processes (VV Abramov, 1988). Therefore, it is clear that when the potential difference between the right and left hemispheres increases, i.e. when the energy metabolism in the right hemisphere is intensified relative to the left hemisphere, then an increase in the functional activity of T and B lymphocytes is observed. The role of the left hemisphere in the regulation of immunological reactions is also interesting. According to neurophysiological studies, reciprocal connections of both hemispheres are known, i.e. high neural activity of one of the hemispheres inhibits the work of the other hemisphere. Since the correlation between the functional activity of T-lymphocytes with local SCP in the right and left temporal areas has a different sign (Table 9.4),then we can talk either about the direct negative effect of the left hemisphere on the activity of T-lymphocytes, or about the indirect effect of this hemisphere on the immune activity through inhibition of the right hemisphere.
In general, we can present the following picture of changes in energy and immune processes, depending on the level of cerebral activation in the development of nonspecific adaptation syndrome. At rest, SCP is higher in the left hemisphere, i.e. with a relatively low average level of cerebral energy metabolism, it is higher in the left dominant in the right-handed hemisphere. Under mild stress in the right hemisphere, energy exchange increases, there is a change in hemispheric relations, which leads to activation of the functional activity of T and B lymphocytes. With a further increase in the level of brain activation, cerebral energy exchange (averaged UPP) increases and the functional activity of T and B lymphocytes decreases.