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Fluoxetine - Prozac : instructions for use and for what it is needed

The pharmaceutical drug Fluoxetine - Prozac has gained great popularity in the market of antidepressant medicines. The therapeutic activity of the active element of the drug is to inhibit the reuptake of serotonin , which is the so-called "hormone of happiness." The drug is effective in the treatment of depressive conditions of various etiologies, nervous appetite disorders and other neuropsychiatric disorders. Due to the possible negative effect of the drug on psychomotor and environmental perception, the selection of dosage should be made by a specialist.

Dosage Form Fluoxetine - Prozac

The antidepressant fluoxetine is available in the form of gelatin capsules, painted in white and blue, with a yellowish-white granular powder inside.

Description and composition of fluoxetine - Prozac

The active substance of the product is represented by fluoxetine hydrochloride , the content of which in one capsule corresponds to 20 mg.

Additional components of the composition:

microcrystalline cellulose;

titanium dioxide;

magnesium stearate;

milk sugar;


silicon dioxide (colloidal);


indigo carmine.

Pharmacological group Fluoxetine - Prozac

Fluoxetine hydrochloride is an antidepressant belonging to the group of selective (selective) serotonin hormone reuptake inhibitors in the neural connections of the central nervous system. The substance is a propylamine derivative. The effect of Fluoxetine leads to an increase in the concentration, strengthening and prolongation of the action of the "hormone of happiness" in the synaptic cleft. With long-term use of the drug, the activity of 5-HT 1 receptors is suppressed. The practical tool does not affect the reuptake of the hormones dopamine and norepinephrine. Also, fluoxetine hydrochloride does not act directly against H-1-histamine, m-cholinergic, serotonin and alpha-adrenergic receptors. The medication does not cause a decrease in the activity of beta-adrenoreceptors of a postsynaptic nature, which compares favorably with most other antidepressants.

Due to the administration of fluoxetine, a decrease in body weight due to the anorexigenic effect may be observed . The tool does not cause orthostatic collapse and sedation. Does not affect the functioning of the cardiovascular system.

Approximately 95% of the total substance is absorbed from the digestive tract. Simultaneous ingestion causes a slight slowdown in absorption. The maximum plasma concentration is reached 6-8 hours after use. The bioavailability of the drug is 60%. Binding to serum blood proteins - more than 90%. It is metabolized in the liver by the demethylation reaction. It is excreted by the intestines and kidneys. The elimination half-life can make from 4 to 16 days. 

Indications for use Fluoxetine - Prozac

The tool is used for the effective treatment of various neuropsychiatric disorders , mainly of a depressive nature. Before use, it is strongly recommended to consult a doctor.

Fluoxetine - of Prozac etc. To Adults

Indications for therapeutic use of fluoxetine in an adult category of patients are the following conditions:

depressive states of various origins ;

bulimia nervosa (bulimic neurosis);

obsessive states (obsessive-compulsive disorders) .

Also, the tool is used as one of the elements of a comprehensive treatment for alcohol dependence.

Fluoxetine - of Prozac etc. A children

Children are contraindicated in the use of a medication due to the lack of authoritative evidence of the effectiveness and safety of fluoxetine in the age group of patients under 18 years of age.

For pregnant and lactating women

During pregnancy and breastfeeding, it is forbidden to take this antidepressant. An exception may be those cases when the likely health benefits of a woman significantly exceed the risks of disturbances in the development of the fetus.


Among the main prohibitions on the use of Fluoxetine are:

period of breastfeeding;

various severe renal impairment;

children under 18 years old;

liver failure;

simultaneous use of pimozide, MAO inhibitors and thioridazine;

convulsions of various genesis;

lactose intolerance;



lactase deficiency and / or glucose-galactose malabsorption;

hypersensitivity to the components of the drug.


diabetes mellitus;

suicidal tendencies;


Dosage and Administration

The medication should be taken orally before, after or during meals. It is recommended to drink funds with a large amount of clean water.

for adults

For the treatment of various kinds of depressive conditions, an initial dose of 20 mg fluoxetine should be taken in the morning. If necessary, this amount can be increased to 40 or 60 mg. The maximum dosage is 80 mg.

In case of obsessive-compulsive disorder (OCD), it is recommended to take from 20 to 60 mg of the drug per day.

Treatment of bulimia nervosa should begin with 60 mg of fluoxetine hydrochloride, divided into 2 or 3 doses. Subsequently, medical adjustments are possible.

The duration of treatment depends on the susceptibility of the patient to the action of the drug and the presence of concomitant pathologies.

for kids

The age category of patients under 18 years of age is strictly contraindicated in taking this drug.

for pregnant and lactating

In the lactation period and during pregnancy, fluoxetine can be used only in cases where the benefit for the woman, expected from the effect of the drug, significantly exceeds the likely negative consequences.

Side effects

bouts of anxiety, excitement, or panic;

feeling dizzy;

decreased libido;


difficulty in digestion, accompanied by pain;

increased likelihood of suicide;

excessive salivation or dry mouth;

significant weight loss;

excessive sweating;


allergic reactions;

irritability and irritability.

Interaction with other drugs

When replacing a medication with a similar agent, it is necessary to take into account a rather long half-life of fluoxetine hydrochloride and its metabolites.

The simultaneous use of the drug with tryptophan, procarbazine, MAO inhibitors and selegiline is contraindicated because of the high likelihood of the manifestation of the so-called " serotonin syndrome ".  

In the case of the recent withdrawal of phenytoin use, intoxication of the body may occur during the use of fluoxetine.

At least 2 weeks should elapse between the end of therapy with MAO inhibitors and the start of fluoxetine administration. After discontinuation of fluoxetine and before starting to use MAO inhibitors, an interval of 5 weeks should be made.

The tool enhances the effect of hypoglycemic drugs.

Perhaps the development of body poisoning when combining drugs with lithium preparations.

special instructions

Throughout the treatment course, the use of alcoholic beverages is prohibited.

In patients with diabetes , glucose levels may change.

Elderly patients are advised to select individual doses of the drug.

Patients with various depressive and other neuropsychiatric disorders are at increased risk for suicidal tendencies. This is especially true for the age group of patients from 18 to 25 years old, with experience in the use of antidepressants.

During the use of Fluoxetine, it is forbidden to drive vehicles, engage in potentially dangerous activities and perform work that requires an increased concentration of attention and reaction speed.

When combining the use of the drug and the conduct of electroconvulsive therapy, the risk of epileptic seizures increases significantly.


Symptoms of poisoning:



mental or motor excitement.

To eliminate the effects of an overdose, sorbent intake and gastric lavage are prescribed. Next, symptomatic drug treatment should be carried out.

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