interactions between cerebral energy and immunological processes. Despite the presence of reliable multiple correlation, the intensity of interaction in the group of middle-aged subjects compared to other groups is lower. Perhaps this is due to the rearrangements that occur with age in the human immune system.
In the work of T.V. Makarova et al. (1999) showed that age-related changes in the immune system are multidirectional. The functional activity of T-lymphocytes progressively decreases, and the proliferative activity of B-lymphocytes, on the contrary, increases. In older people (60-75 years), there is a tendency to decrease T-lymphocytes and impaired ratio of immunoregulatory subpopulations of T-lymphocytes. At the same time, there is an increase in the relative content of B-lymphocytes without a pronounced change in the level of immunoglobulins of classes A, M, G.
Since the maintenance of high activity of T-and B-lymphocytes requires, among other things, functional neurophysiological rearrangements in the elderly, it is in this age range that the immune system is most sensitive to fluctuations in the intensity of cerebral energy metabolism. This probably explains the low threshold of the immune system of the elderly to the action of stress.
Conclusion
Neuro-immune interaction, allowing the body to adapt to environmental conditions, is carried out mainly with the participation of the endocrine system through the hypothalamic-pituitary-adrenal axis, as well as through the autonomic nervous system. With an increase in the level of energy metabolism in the brain as a whole, without changing the hemispheric relations, a decrease in the immune activity is observed, which is probably realized through a stress-like mechanism and the activation of HGSN. This is also indicated by the correlation of the level of stress hormone cortisol in the blood with UPP and immune responses. The nature of inter-hemispheric relations affects the immune activity. The increase in activation of the right temporal region with respect to the left (i.e. under mild stress) coincides with the increase in the proliferative activity of T and B lymphocytes.This fact confirms the idea of the disparity of both hemispheres in the regulation of autonomic fu Commands. Since, according to SCP, hemispheric relations and general cerebral energy exchange
regularly changing under the influence of stress , we can assume the existence of a single neuro-endocrine mechanism of the relationship of the energy characteristics of the brain with indicators of the immune response.