The penetration of industrial and other exogenous poisons into the body most often occurs through the respiratory system. Importance kmeet and skin contact with liquid toxic substances (tetraethyl lead and mixtures thereof, amidonitrosoedineniya benzene, various solvents and so forth.). The effect of poisons on peripheral nerves is determined by the degree of solubility of these substances in lipoids, which are rich in the shells of nerves, and by the characteristics of the nerves themselves, their blood circulation, and their ability to absorb toxic substances. An important role is played by a violation of enzymatic processes, to which the nervous system is extremely sensitive. The mechanism of poisoning by some poisons is associated with their blocking effect on sulfhydryl groups. Poisons such as arsenic, mercury, and other metals are enzyme inhibitors. When poisoning with arsenic, lead, mercury, tricresylphosphate, the content of pyruvic acid in the blood rises, the balance of vitamin B1 is disturbed, and the activity of cholinesterase changes buy antidepressant every day .
Under the influence of toxins, the initial breakdown of myelin occurs, which, being an autoallergen , causes a number of autoimmune reactions, including autoaggressive ones . Microscopically during acute intoxication, swelling or wrinkling of gliosis cells is found, and in nerve conductors, swelling of myelin fibers and demyelination are found . In chronic poisoning, the duration of the effects of poisons and the severity of damage to internal organs, especially the liver, are important .