Simplified Glucose Metabolism in the Brain

The high rate of energy metabolism of the brain is associated with intensive formation of macroergic compounds – ATP and creatine phosphate. The creatine phosphate – creatine system plays a role in stabilizing the level of macroergic compounds of the brain .

End products of energy metabolism. Change in acid-base balance during energy metabolism . In glycolysis and the Krebs cycle, the end products of metabolism are lactate, carbon dioxide and water. CO 2 partially reacts with water to form H + and HCO 3 – ions . Therefore, in general, during the catabolic conversion of glucose and other substances, the acid-base equilibrium (ASR) shifts to the acid side. However, there are effective mechanisms for maintaining the stability of the acid-base balance in the brain, which will be discussed in the next section.

It is customary to use pH, the negative decimal logarithm of the concentration of hydrogen ions, to characterize the CRR. Depending on which side the reaction of the body’s body fluids changes, there are two types of ASR disorders. A decrease in pH compared to a normal level is called acidosis , and an increase is called alkalosis 

local_offerevent_note September 20, 2019

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